:: Volume 25, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(5): 52-66 Back to browse issues page
Effect of protamine and Its abnormalities on male fertility potential
Tahereh Rahiminia 1, Javad Amini Mahabadi2 , Ehsan Farashahi Yazd3 , Ali Reza Talebi3
1- Gametogenesis Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran , tahereh.rahiminia@gmail.com
2- Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran
3- Research and Clinical Centre for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:   (444 Views)
Background and Aim: All studies on mammals and rodents have revealed the presence of protamine 1 (P1) and protamine 2 (P2) in the sperm which is indicative of the expression of these two genes at different molecular levels. The aim of this study was to investigate the effect of protamine and its disorders on male fertility potential.
Materials and Methods: Using keywords of sperm, protamine, male infertility, and chromatin we searched PubMed and Google Scholar databases between 1980 and 2020.
Results: Sperm concentration, motility, and morphology in the patients with variable P1/P2 ratios were significantly reduced compared to those in the individuals with normal P1/P2 ratios which were directly associated with reduced fertility rate. The most common protamine abnormality in the infertile men was increased P1/P2 ratio which was frequently associated with a decreased level of P2 and increased level of P2 precursors. Increased levels of histone B2 (H2B) in sperm and lower levels of protamine have been reported. Any disturbances in the histone expression process cause inconvenient early chromatin condensation, transcription arrest, as well as spermatogenesis failures.
Conclusion: The results of this study showed that the protamine transcripts ratio can be used as a marker for male fertility. Histones/protamines mRNAs ratios are important for sperm quality and therefore can be used as predictors for male infertility. Altered levels of protamines may result in an increased susceptibility to injury in the sperm DNA causing infertility or poor outcome in assisted reproduction.
Keywords: Male infertility, Sperm, Protamine, Chromatin
Full-Text [PDF 310 kb]   (253 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/10 | Accepted: 2020/08/8 | Published: 2020/11/22

XML   Persian Abstract   Print

Volume 25, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page