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Elevated white blood cell counts and risk of metabolic syndrome: a dose-response meta-analysis
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Roholla Hemmati1    , Sedighe Rastaghi2 , Mohammad Sarmadi3 , Zeinab Bidel 4, Wahideh Menati5 |
1- Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
2- Department of Biostatistics, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3- Department of Environmental Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
4- Collaboration Center of Meta-Analysis Research, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran , zeinab.bidel@yahoo.com
5- Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran. |
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Abstract: (3915 Views) |
Background and Aim: Elevated white blood cell count has been a known risk factor for cardiovascular diseases. Cardiometabolic diseases have some risk factors in common. Therefore, we assessed the association between elevated white blood cell counts and risk of metabolic syndrome using dose-response meta-analysis method.
Materials & Methods: We searched for observational studies including white blood cell counts as exposure and metabolic syndrome as outcome through international databases (PubMed, Embase, and Scopus) up to October 2017. Multi-adjusted odds ratio (OR) and corresponding 95% confidence intervals (CIs) were extracted from eligible articles. Random-effects model was used to estimate the relationship between elevated white blood cell counts and risk of metabolic syndrome.
Result: After independent screening, 17 studies were selected and included in this meta-analysis. Compared with lowest quartile of white blood cell, OR for highest quartile was 2.35 (CI 1.81 to 3.05). Ten studies were included in dose-response meta-analysis and the result showed OR 1.21 (CI 1.10 to 1.34) per unit increase (1000 ml) in white blood cell counts. We did not find any evidence of publication bias using Egger’s regression (P=0.11).
Conclusion: This meta-analysis suggested that there might be a dose response association between higher white blood cell count as an inflammatory factor and increased risk of metabolic syndrome. Also risk of metabolic syndrome is higher in the women and individuals of older age. In order to draw causal inference propective studies using genetic factors will be necessary. |
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| Keywords: White blood cell, Metabolic syndrome, Systematic review and meta-analysis |
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Full-Text [PDF 429 kb]
(1636 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2018/12/30 | Published: 2019/06/15
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