:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 103-113 Back to browse issues page
The effects of crocin on the serum levels of sex hormone and NO in streptozotocin – induced diabetic rats.
Hananeh Bahojb Soldozi 1, Faramarz Jalili 1, Maryam Sohrabi 2, Zahra Keshtmand Dr3, Cyrus Jalili Dr * 4
1- Students Research Committee, KermanshahUniversity of Medical Sciences, Kermanshah, Iran.
2- Medical Biology Research Center, Kermanshah University of Medical Sciences,Kermanshah, Iran.
3- Assistant Professor Islamic Azad University, Tehran Science Research Branch, Iran.
4- Associated Professor Medical Biology Research Center, Kermanshah University of Medical Sciences,Kermanshah, Iran , cjalili@yahoo.com
Abstract:   (228 Views)
Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals. We evaluated the effects of crocin on the reproductive parameters of the STZ –induced diabetic male Wistar rats.
Materials and Method: Rats were made diabetic with STZ (55 mg/kg). The rats were divided randomly into 8 groups of seven: control group (normal Saline), STZ induced diabetic group, groups receiving 12.5, 25 and 50 mg/kg doses of crocin and STZ induced diabetic groups receiving the same doses of the crocin. These animals were kept under experimental conditions for 30 days. LH, FSH, testosterone and insulin hormones are measured .The significance of the results was examined by ANOVA statistical method.
Results:
Groups receiving crocin and STZ simultaneously showed significant increase (P <0.05) in the levels of LH, FSH, testosterone and insulin hormones compared to the groups receiving STZ.
Conclusion: Crocin compensates for the most of degenerative effects of STZ-induced diabetes on the reproductive system of the male rats. It is a rich source of antioxidants and can positively affect most of the reproduction indexes in the rats in a dose depend manner.
Keywords: Crocin, Streptozocin, Rat, Diabetes.
 
Received: Nov 21, 2017     Accepted: Apr 8, 2018
Keywords: Crocin, Streptozocin, Rat, Diabetes.
Full-Text [PDF 3926 kb]   (77 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
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