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:: Volume 22, Number 3 (Scientific Journal of Kurdistan University of Medical Sciences 2017) ::
SJKU 2017, 22(3): 74-84 Back to browse issues page
Assessment of the antinociceptive, antiinflammatory and acute toxicity effects of Ducrosia anethifolia essential oil in mice
Mahtab Asgari Neamatian1, Dr Parichehr Yaghmaei2, Saeed Mohammadi 3
1- Instructor Department of Biology, Payam-noor University, Hamadan Branch, Tehran, Iran.
2- Associate Professor Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran , smiauhphd.sm@gmail.com
Abstract:  
Background and Aim: Ducrosia anethifolia (Moshgak) is one of the most important herbs used in traditional medicine for treatment of anxiety and insomnia.  The aim of this study was to evaluate the anti-inflammatory and analgesic effects of Ducrosia anethifolia leaf essential oil (DAEO) in male mice.
Material and Methods: This experimental study included 84 male mice. For evaluation of pain, we used pain assessment tests (writhing, tail-flick and formalin) and animals were divided into control group and experimental groups. The experimental groups treated with the essential oil (30, 100 and 300mg/kg), morphine, and naloxone plus 300 mg/kg of essential oil. We used Xylene test for evaluation of anti-inflammatory effect, and divided the animals into 5 groups: control, DAEO (10, 50, and 100 mg kg) and dexamethasone.
Results: In tail-flick and writhing tests, application of a dose of 300 mg/kg of DAEO showed a significant analgesic effect (P<0.01) in the test groups compared to that in the control group. In the formalin test, a dose of 100 mg/kg of DAEO in the chronic phase reduced pain scores in the test groups compared to the scores in the control group (P <0.05). In addition, in Xylene test, treatment with both doses of 50 and 100 mg/kg of essential oil led to reduced ear swelling in the rats (3.8 ±0.1, 4.1 ±0.8, respectively), compared to that in the control group.
Conclusion: Intraperitoneal administration of DAEO can produce analgesic and anti-inflammatory effects.
Key words: Anti-inflammatory, Analgesic, Ducrosia anethifolia, Medicinal plants.
 
Received: Sep 24, 2016      Accepted: Feb 7, 2017
Keywords: Anti-inflammatory, Analgesic, Ducrosia anethifolia, Medicinal plants.
Full-Text [PDF 247 kb]      
Type of Study: Research | Subject: General
Received: 2017/07/24 | Accepted: 2017/07/24 | Published: 2017/07/24
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Volume 22, Number 3 (Scientific Journal of Kurdistan University of Medical Sciences 2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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