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The Local Effect of rosemary essence on healing of the cutaneous incisional wounds in the rats infected with Staphylococcus aureus
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Esmael Izadpanah1   , Arvin Rahmanpour 2 |
1- Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. 2
2- Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj , Rahmanpour_arvin@yahoo.com |
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Abstract: (4718 Views) |
Background and Aim: Wound infections caused by Staphylococcus aureus, substantially have been on the rise in recent years. There have been many reports on antimicrobial and inflammatory properties of rosemary, but no study has been performed on this subject. The aim of this study was to evaluate local effects of rosemary essence on healing of the cutaneous incisional wounds in the rats infected with Staphylococcus aureus.
Materials and Methods: This study included 45 Wistar male rats with mean weight of 210±10 g. After general anesthesia and making a 1.5*1.5 cm. square wound in the area between the shoulders, 0.5 ml. of the bacterial suspension containing 1.5*106 CFU/ml Staphylococcus aureus was applied to the wounds. Then, the rats were divided randomly into three groups of 15; control, rosemary1.5 % and 3% groups. Each group was also divided into 5subgroups of 3 animals. Punch biopsies were obtained from the groups on different days. At the end of the 4th, 8th, 12th, 16th and 20th days, biopsies were taken by a special punch.
Results: The results of this study showed that use of rosemary enhanced significantly wound healing and increased the number of macrophages, fibroblasts and blood vessels, and reduced the number of neutrophils in the wound area in the experimental groups compared to those in the control group. Comparison of the number of the colonies of Staphylococcus aureus in infected wounds between the groups also showed that use of rosemary led to a significant reduction in colony count in the experimental groups compared to the results of the control group )p<0.01 , P<0.05).
Conclusion: The results of this study showed that rosemary essential oil can have beneficial effects on the healing of incisional wounds infected with Staphylococcus aureus. In order to determine mechanism of action of rosemary essential oil, further studies are recommended.
Keywords: Rosemary essence, Staphylococcus aureus, wound healing, Rats.
Received: Mar 04, 2017 Accepted: May 06, 2017 |
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| Keywords: Rosemary essence, Staphylococcus aureus, wound healing, Rats. |
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Full-Text [PDF 526 kb]
(3075 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2017/07/24 | Accepted: 2017/07/24 | Published: 2017/07/24
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