Comparison of the effect of single and multiple-dose methotrexate therapy on tubal patency in women with ectopic pregnancy
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Taravat Fakheri , Nazanin Farshchian , Mansour Rezaie , Seyedeh Mozhgan Seyedzadeh 1 |
1- , Sm.seyedzadeh@kums.ac.ir |
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Abstract: (5062 Views) |
Background and Aim: Ectopic pregnancy is one of the leading causes of death among the women of reproductive age. Injection of single or multiple doses of methotrexate can be used as a therapeutic approach. The aim of this study was to compare the effect of single and multiple-doses of methotrexate therapy on the tubal patency in women with ectopic pregnancy.
Material and Methods: This was an interventional study and included 80 patients with ectopic pregnancy who had been treated with a single dose or multiple doses of methotrexate. After 3 months of hospitalization and treatment, hysterosalpingography was conducted to assess tubal patency. Data were analyzed using SPSS version 21.
Results: The frequencies of ipsilateral tubal obstruction were 12 (30%) and 3 (7.5%) in the patients who had received multiple-doses of methotrexate and single-dose methotrexate respectively. Also, 33 (82.5%) patients in the single-dose methotrexate group and 18 (45%) patients in the multiple-dose methotrexate group did not have bilateral obstruction. There was a significant difference in the frequencies of tubal obstruction between the two groups treated with single and multiple doses of methotrexate (P<0.05).
Conclusion: The incidence of tubal obstruction in women with ectopic pregnancy was significantly lower in single-dose methotrexate group compared to multiple dose methotrexate groups.
Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates.
Received: Apr 28, 2015 Accepted: Nov 23, 2015 |
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Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates. |
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Full-Text [PDF 151 kb]
(2542 Downloads)
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Type of Study: Original Research |
Subject:
General Received: 2016/02/8 | Accepted: 2016/02/8 | Published: 2016/02/8
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