[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations89875404
h-index3725
i10-index235137

 

..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Volume 20, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) ::
SJKU 2015, 20(4): 83-90 Back to browse issues page
Effects of drug substance crystal (methamphetamine) on histopathology and biochemical parameters of kidney in adult male mice
Shabnam Mohammadi , Zahra Pakrouh 1, Mahin Teimouri , Saedeh Haji Pour , Mehdi Karimi , Maryam Mohammadi , Ali Mohammad Pour , Mohammad Hossein Tani Pour , Isaac Hashemi , Mohammad Sookhtanlu , Kamyar Tavakkoli , Fatemeh Mohammadzadeh
1- , Dr.paper57@gmail.com
Abstract:   (10644 Views)

Background and Aim: Methamphetamine causes damage in different body organs. The aim of this study was to investigate the effects of methamphetamine on morphometric changes and biochemical parameters in kidney of adult mice. 

Material and Methods: In this experimental study, 56 mice were randomly divided into 7 groups: control and 6 experimental groups. Experimental groups 1, 2 and 3 received methamphetamine 5, 10 and 20 mg/kg respectively for 10 days.  Experimental groups 4, 5 and 6 received methamphetamine (5, 10 and 20 mg/kg) respectively for 40 days. After 10 and 40 days, kidneys of the mice of the experimental groups were removed and after tissue processing and imaging, volume of kidney and glomerulus were measured by using cavalieri's principle. In addition blood urea and creatinine levels were measured. Using SPSS software, data were analyzed by means of ANOVA.    

Results: Histopatological study showed that methamphetamine increased renal damage in a dose dependent manner. High doses of methamphetamine caused a moderate lobulation, glomerulosclerosis and kidney congestion. There was also a significant difference between the experimental (groups 3 to 6) and control groups in regard to the volumes of kidney and glomerulus (P=0.000).     

Significant differences were found in the level of urea in group 6 and creatinine levels in all experimental groups compared to those of control group (P=0.000).    

Conclusion: Use of 10 mg/kg of methamphetamine for 40 days led to destructive effects on kidney tissue. Also, it increased serum levels of urea and creatinine.

Keywords: Methamphetamine, Kidney, Mice.

 

Received: Dec 31, 2014      Accepted: Jun 6, 2015

Keywords: Methamphetamine, Kidney, Mice
Full-Text [PDF 560 kb]   (6882 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2015/10/19 | Accepted: 2015/10/19 | Published: 2015/10/19
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mohammadi S, Pakrouh Z, Teimouri M, Haji Pour S, Karimi M, Mohammadi M, et al . Effects of drug substance crystal (methamphetamine) on histopathology and biochemical parameters of kidney in adult male mice. SJKU 2015; 20 (4) :83-90
URL: http://sjku.muk.ac.ir/article-1-1970-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4645