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The effect of donepezil on morphine-induced withdrawal syndrome in rats
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Esmael Izadpanah1   , Ali Abdolmaleki2 , Saro Khatibi Baneh3 , Majid Ghaderi4 , Soleiman Kurd5 , Kambiz Hasanzadeh6 |
1- Kurdistan University of Medical Sciences
2- Islamic Azad University of Hamedan
3- Payame Noor University, Tehran
4- Razi University, Kermanshah
5- Kurdistan University
6- Kurdistan University of Medical Sciences , kambizhassanzadeh@gmail.com |
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Abstract: (13152 Views) |
| ABSTRACT
Background and Aim: Long-term exposure to opiates induces physical and psychological dependency. Despite a large number of studies on this subject, cellular mechanism involved in this phenomenon is not yet exactly clear. In this study, we investigated the effects of donepezil, an acetylcholine esterase inhibitor, on morphin-induced withdrawal symptoms in rats.
Material and Method: In this experimental study,6 groups of male Sprague Dawly rats weighting between 225 and 300 g, received 10 mg/kg , ip morphine/ day in addition to 1 ml/kg,ip saline or 0.5, 1 and 1.5 mg/kg, ip donepezil. In order to induce dependency, morphine was administered subcutaneously every 12 hours for nine days. On the ninth day,30 minutes after the last dose of morphine, control groups received 1 ml/kg, ip saline and experimental groups received ip donepezil. After 30 min, naloxone (4 mg/kg, ip) were administered for all groups and the withdrawal symptoms including: jumping, rearing, genital grooming, abdomen writhing, body grooming and wet dog shake, were recorded for 60 minutes.
Results Our results showed that donepezil decreased withdrawal symptoms, also it could attenuate the total withdrawal score, significantly.
Conclusion: The results of this study showed that donepezil as an acetylcholine esterase inhibitor, could decrease withdrawal symptoms in rats.
Key words: Donepezil, Morphine, Dependency, Withdrawal symptoms
Received: Jun 15, 2012 Accepted: Oct 10, 2012
Conflict of interest: None declared |
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| Keywords: Donepezil, Morphine, Dependency, Withdrawal symptoms |
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Full-Text [PDF 241 kb]
(2675 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2013/10/4 | Accepted: 2013/10/9 | Published: 2013/10/9
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