[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations89875404
h-index3725
i10-index235137

 

..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Volume 26, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2021) ::
SJKU 2021, 26(3): 13-24 Back to browse issues page
Effect of High-Intensity Interval Training and Lactobacillus Rhamnosus Probiotic Consumption on TLR4 and MYD88 Expression in Gut Tissue in Animal Model of Non-Alcoholic Fatty Liver
Masoumeh Mazinani1 , Saeedeh Shadmehri 2, Hossein Shirvani3
1- Department of Physical Education and Sport Science Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Science Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran , saeedehsh61@gmail.com
3- Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (1982 Views)
Background and Aim: The liver is exposed to large amounts of toll-like receptor ligands due to increased bacterial growth and increased intestinal permeability in patients with fatty liver disease. The aim of this study was to investigate the effect of high-intensity interval training and Lactobacillus Rhamnosus probiotic consumption on TLR4 and MYD88 expression in gut tissue in an animal model of non-alcoholic fatty liver.
Materials and Methods: In this experimental study, 40 rats (weighing 200-250 gr) were selected and randomly divided into 5 groups including healthy control, fatty liver, fatty liver + HIIT, fatty liver + probiotic, and fatty liver + HIIT + probiotic groups. In order to induce fatty liver, oral tetracycline 140 mg/kg/day in 2 ml of water in form of a solution was given to the rats by gavage for 7 days. HIIT exercise program performed on treadmill five sessions per week for 5 weeks. Data were analyzed by one-way ANOVA and Tukey post hoc tests.
P <0.05 was considered significant.
Results: The results showed that TLR4 gene expression was significantly lower in HIIT, probiotic, and also HIIT + probiotic groups than in the fatty liver group (p=0.001). Also, the expression of the MYD88 gene in intestinal tissue was significantly lower in HIIT, probiotic and HIIT+probiotic groups than that in the fatty liver group (p=0.001).
Conclusion: Expression of TLR4 and MYD88 genes in adipose tissue induced by fatty liver, can be reduced by HIIT and probiotic intake. Therefore, these interventions can be considered as a non-pharmacological strategy in the treatment of fatty liver.
Keywords: Exercise, Non-alcoholic fatty liver, Inflammation, Probiotic
Full-Text [PDF 576 kb]   (875 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2019/10/19 | Accepted: 2021/01/11 | Published: 2021/07/23
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mazinani M, shadmehri S, shirvani H. Effect of High-Intensity Interval Training and Lactobacillus Rhamnosus Probiotic Consumption on TLR4 and MYD88 Expression in Gut Tissue in Animal Model of Non-Alcoholic Fatty Liver. SJKU 2021; 26 (3) :13-24
URL: http://sjku.muk.ac.ir/article-1-5461-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.07 seconds with 44 queries by YEKTAWEB 4645