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:: Volume 25, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(4): 1-19 Back to browse issues page
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial
Gholamreza Nasiri1 , Ali Bastani2 , Ali Akbar Haji-Aghamohammadi3 , Mohamadreza Rashidi Noosh abadi4 , Parviz Shahmirzalou5 , Hossein Khadem Haghighian 6
1- Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of Internal Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. ORCID ID: 0000-0002- 5434-4939
3- Department of Internal Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4- Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of Biostatistics, Khoy university of Medical Sciences, West Azerbaijan, Iran
6- Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran , khademnut@yahoo.com
Abstract:   (261 Views)
Background and Aim: The purpose of this study was to evaluate the effects of probiotic and alpha-lipoic acid (ALA) supplements, on appetite in overweight people.
Materials and Methods: This study included two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight people were randomly divided into 4 groups: Isocaloric diet with probiotic (500mg), isocaloric diet with ALA (600mg) and probiotic, isocaloric diet with ALA and isocaloric diet with placebo groups. In the second phase, the participants received normal diet with the above - mentioned supplements. At the beginning and end of the first phase and at the end of the second phase, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, C-reactive protein (CRP), and appetite were evalauted. We used SPSS software for statistical analysis. Independent sample t-test and ANOVA were used to compare the alterations in the mean values among the groups.
Results: At the end of the first phase, the level of anthropometric changes, inflammatory factor and appetite were significant in the intervention groups, but these changes were higher in the probiotic + ALA group than in the other groups (P <0.05). At the end of the second phase we found significant changes only in the probiotic + ALA group (P<0.05).
Conclusion: Addition of probiotic and ALA supplements to the normal diet can be effective in appetite and weight management and also maintainance of weight loss which may be due to decreased inflammation.
Keywords: Probiotic, Alpha lipoic acid, Appetite, Overweight
Full-Text [PDF 449 kb]   (199 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/10/4 | Accepted: 2020/02/5 | Published: 2020/09/22
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Nasiri G, Bastani A, Haji-Aghamohammadi A A, Rashidi Noosh abadi M, Shahmirzalou P, Khadem Haghighian H. Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial. SJKU. 2020; 25 (4) :1-19
URL: http://sjku.muk.ac.ir/article-1-5422-en.html


Volume 25, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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