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:: Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) ::
SJKU 2017, 22(4): 8-17 Back to browse issues page
Protective effects of hydro-alcoholic garlic extract on spermatogenic disorders in streptozotocin-induced diabetic C57BL/6 mice
Ali Soleimanzadeh Dr 1, Farin Malekifard 2, Alireza Kabirian 3
1- Assistant Professor Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , a.soleimanzadeh@urmia.ac.ir
2- Department of Microbiology, Faculty of veterinary medicine, Urmia University, Urmia, Iran.
3- Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Abstract:  
Background and Aim: Diabetes can cause sexual dysfunction including spermatogenic disorders in the diabetic patients. The aim of the present study was to investigate the antioxidant effects of garlic extract in diabetic mice.
Materials and Methods: Diabetes was induced by multiple low-dose streptozotocin injections (40 mg/kg/day for 5 consecutive days), in male C57BL/6 mice (15-20 gr body weight). After induction of diabetes, the mice were divided into 4 groups: group 1 (normal control group); group 2 (diabetic control group); group 3 (treatment with garlic extract 200 mg/kg for 35 days) and group 4 (treatment with garlic extract 400 mg/kg for 35 days). Mice were euthanized on the 35th day and serum testosterone levels were estimated. Testes and epididymis were removed for sperm evaluation and measurement of nitric oxide (NO) levels and total antioxidant capacity (TAC). 
Results: Garlic treatment significantly improved semen parameters and increased serum level of testosterone (p<0.05). Aside from reducing the elevated tissue nitric oxide level, garlic increased total antioxidant capacity in testis tissue samples.
Conclusion: This study showed potent antioxidant effect of hydro-alcoholic garlic extract on the testes of mice against type 1 diabetes -induced oxidative stress.
Keywords: Type 1 diabetes, Garlic, Spermatogenesis, Nitric oxide, Total antioxidant capacity.
Received: Nov 21, 2016       Accepted: May 13, 2017
Keywords: Type 1 diabetes, Garlic, Spermatogenesis, Nitric oxide, Total antioxidant capacity.
Full-Text [PDF 1516 kb]      
Type of Study: Research | Subject: General
Received: 2017/09/18 | Accepted: 2017/09/18 | Published: 2017/09/18
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Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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