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:: Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) ::
SJKU 2017, 22(4): 1-7 Back to browse issues page
The effect of Licophar on prevention of oral mucositis caused by chemotherapy in cancer patients
Bayazid Ghaderi Dr * 1, Shila Aghayani Dr2, Nasrin Daneshkhah 3, Nasrin Moghimi Dr4
1- Assistant Professor Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran , bayazidg@yahoo.com
2- Internal Medicine Department, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Instructor Paramedical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Associated Professor Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
Abstract:   (1076 Views)
Background and Aim: Oral mucositis is a common and debilitating complication that can occur after administration of certain chemotherapy drugs. Yet, no preventive therapy has been recommended for this complication. This study aimed to determine the effect of licophar on prevention of chemotherapy-induced oral mucositis.

Methods and method: This was a double blind RCT which was performed in Sanandaj City and included 40 patients with colon and gastric cancer who had received chemotherapy for the first time between 1390 and 1391. 5-FU (FOLFOX4) was prescribed for the patients. Licophar was given to the intervention group, and control group received placebo. The patients were examined for the presence or absence of oral mucositis. Using SPSS.18 software, data were analyzed by descriptive statistics and Mann-Whitney tests, independent T test and chi square.

Results: In our study, 25 patients (62.5%) were male and 15 (37.5%) were female. The mean age of the participants was 53.20 ±8.77 years and the mean duration of treatment was 5.05 ±3.15 months. Oral mucositis was not observed in the intervention group, but 35% of the patients in the control group developed this disorder (p <0.01). There were no statistically significant difference between the two groups in relation to age and gender (p> 0.05).

Conclusion: Licophar is effective for prevention of oral mucositis induced by chemotherapy.

Keyword: Licophar, Oral mucositis, Chemotherapy.

Received: Jul 14, 2016       Accepted: May 1, 2017
Keywords: Licophar, Oral mucositis, Chemotherapy.
Full-Text [PDF 143 kb]   (408 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/09/18 | Accepted: 2017/09/18 | Published: 2017/09/18
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Volume 22, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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