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:: Volume 12, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2008) ::
SJKU 2008, 12(4): 16-22 Back to browse issues page
Randomized control trial on the effect of pethidine versus tramadol on labour pain relief, labour duration, infants` apgar score and maternal complications in primiparous women
F Seyedalshohadaei , F Zandvakili , SH Sanaei , M Rezaie
Abstract:   (23273 Views)

  ABSTRACT

  Background and Aim: One of the basic principles of modern obstetrics is to provide adequate analgesia. An analgesic should have potent analgesic efficacy and minimal side effects to be suitable for pain relief during labour. The aim of this study was to evaluate and compare the analgesic efficacy and adverse effects of tramadol and pethidine on labour pain, labour duration, apgar score of the infants and maternal complications in primiparous women.

  Materials and Methods: This was a triple-blind randomized control trial. 30 full term parturient women were randomly assigned to one of tramadol or pethidine groups. Inclusion criteria were full term primiparous women without high risk pregnancy in active phase of labour, with 4 cm dilatation of cervix. Lack of induction of delivery, lack of pregnancy complications and drug reactions were regarded as other inclusion criteria. In active phase of delivary vital signs of the parturient women recorded. The pain was measured by means of NRS score. Group I received 50 mg pethedine group II, 50 mg tramadol in 200 cc Ringer solution, intravenously. The vital signs and pain were reassessed after one hour. The mothers and their fetuses were under control for potential complications. Collected data were introduced into SPSS soft ware and analyzed by means of t-test and X². p<0.05 was regarded statistically significant.

  Results: There was no significant difference in relation to age, maternal weight, maternal educational status, gestational age and infant`s weight between the two groups. There was no significant difference between the decrease in the mean systolic and diastolic blood pressures in the two groups. Maternal Side effects such as nausea, vomiting and drowsiness occurred more frequently in pethidine group (p≤0.05). There was no significant difference between the durations of active phase of labour in the two groups. Mean value of the first minute apgar score in tramadol and pethidine groups were 8.87 ±0.516 and 8.86 ±0.363 respectively. The m ean value of the fifth minute apgar score in tramadol and pethidine groups were 9.60±0.507 and 9.57±0.514 respectively (p>0.05). The mean values of pain reduction assessed by VAS score were 1.28±1.63 for pethidine group and 1.00±1.30 for tramadol group ) p≤0.05).

  Conclusion: We conclude that pethidine has more analgesic effect than tramadol on labour pain but frequency of side effects such as nausea and vomiting was higher with pethidine administration. Both drugs can cause shortening of active phase of labour. Apgar score was not influenced by any of the two drugs.

Keywords: Key words: Pethidine, Tramadol, Labour pain.
Full-Text [PDF 112 kb]   (2205 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2009/04/13 | Published: 2008/03/15
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Seyedalshohadaei F, Zandvakili F, Sanaei S, Rezaie M. Randomized control trial on the effect of pethidine versus tramadol on labour pain relief, labour duration, infants` apgar score and maternal complications in primiparous women. SJKU 2008; 12 (4) :16-22
URL: http://sjku.muk.ac.ir/article-1-81-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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