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:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 1-11 Back to browse issues page
Effects of vitamin D supplementation and resistance training on insulin resistance, lipid profile and body fat percentage in T2D men with vitamin D deficiency.
Ali Dadrass 1, Khalid Mohammadzadeh Salamat Dr 2, Kamaleddin Hamidi Dr3, Kamal Azizbeigi Dr4
1- Department of Physical Education and Sport Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
2- Assistant Professor Department of Physical Education and Sport Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , kh.mohamadzadeh@gmail.com
3- Assistant Professor Department of Biology, Mohaggeg Ardabili University, Ardabil, Iran.
4- Assistant Professor Department of Physical Education and Sport Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
Abstract:   (1351 Views)
Background and Aim: The aim of this study was to investigate the effects of vitamin D supplementation during progressive resistance training on insulin resistance, blood lipids and body fat percentage in T2D men with vitamin D deficiency.
Methods: Forty-eight men with T2D participated in the study voluntarily and were randomly assigned to 4 groups (n=12) including, resistance training (RT), vitamin D supplementation with resistance training (RT+VD), vitamin D supplementation (VD), and control groups (CON).The intervention lasted 12 weeks. VD group took 50000 IU of vitamin D supplements every two weeks, RT group performed resistance exercise 3 times /week, RT+VD group received vitamin D supplements and performed resistance training, and CON group maintained normal daily life pattern. Body fat percentage, 25(OH) D, blood lipids, glucose and insulin were measured before and after the intervention. HOMA-IR was used to measure insulin resistance
Results: There was a significant difference in HOMA-IR between the groups which had received vitamin D supplements (P<0.05). Furthermore, the highest reduction rate in the body weight, BMI, body fat percentage, HbA1c, fasting glucose and insulin were observed in RT+VD group.
Conclusion: It was concluded that use of vitamin D for 12 weeks during progressive resistance training would have positive effects on insulin resistance in T2D men with vitamin D deficiency. Vitamin D supplements can be used as an effective method to reduce diabetes symptoms.
Key words: Diabetes, Resistance training, Vitamin D, Insulin resistance.
 
Received: Oct 11, 2017     Accepted: Feb 13, 2018
Keywords: Diabetes, Resistance training, Vitamin D, Insulin resistance.
Full-Text [PDF 910 kb]   (440 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
References
1. Seshadri KG, Tamilselvan B, Rajendran A. Role of vitamin D in diabetes. J Clin Endocrinol Metab 2011; 12: 47-56. [DOI:10.4021/jem23w]
2. Ramachandran A, Snehalatha C, Ma RC. Diabetes in south- East Asia: An update for 2013 for the IDF Diabetes Atlas. Diabetes Res Clin Pract 2014; 103: 231-7. [DOI:10.1016/j.diabres.2013.11.011]
3. Unwin N, Whiting D, Guariguata L, Ghyoot G, Gan D. IDF Diabetes Atlas. 5nd ed. Belgium: International Diabetes Federation (US), 2011: 1-135.
4. Badawi A, Klip A, Haddad P, Cole DEC, Bailo BG, El Sohemy A, et al. Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes 2010; 26; 173-86. [DOI:10.2147/DMSO.S9089]
5. Canadian Diabetes Association. The prevalence and costs of diabetes. 2012, Available from: http://www.diabetes.ca/.
6. Durmaz ZH, Demir AD, Ozkan T, Kılınç C, Güçkan R, Meral Tiryaki M. Does vitamin D deficiency lead to insulin resistance in obese individuals?. Biomed Res 2017; 28: 7491-7.
7. Kim HJ, Kang CK, Park H, Lee MG. Effects of vitamin D supplementation and circuit training on indices of obesity and insulin resistance in T2D and vitamin D deficient elderly women. J Exerc Nutr Biochem 2014; 18: 249-57. [DOI:10.5717/jenb.2014.18.3.249]
8. Zuk A, Fitzpatrick T, Rosella LC. Effect of Vitamin D3 supplementation on inflammatory markers and glycemic measures among overweight or obese adults: a systematic review of randomized controlled trials. PloS One 2016 26; 11: e0154215.
9. Marmett B, Nunes RB. Resistance and Aerobic Training in the Treatment of Type 2 Diabetes Mellitus. J Diabetes Metab Disord Control 2017; 4: 00126.
10. Gray SR, Baker G, Wright A, Fitzsimons CF, Mutrie N, Nimmo MA. The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation. Prev Med 2009; 48: 39-44. [DOI:10.1016/j.ypmed.2008.10.013]
11. Miller EG, Sethi P, Nowson CA, Dunstan DW, Daly RM. Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes. Eur J Appl Physiol 2017; 117: 1669-78. [DOI:10.1007/s00421-017-3657-2]
12. Libardi CA, De Souza GV, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc 2012; 44: 50-6. [DOI:10.1249/MSS.0b013e318229d2e9]
13. Salamat KM, Azarbayjani MA, Yusof A, Dehghan F. The response of pre-inflammatory cytokines factors to different exercises (endurance, resistance, concurrent) in overweight men. Alexandr J Med 2016; 52: 367-70. [DOI:10.1016/j.ajme.2015.12.007]
14. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc 2010; 85: 752-8. [DOI:10.4065/mcp.2010.0138]
15. Jackson AS, Pollock ML. Practical assessment of body composition. Phy Sport Med 1985; 13: 76-90. [DOI:10.1080/00913847.1985.11708790]
16. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systemic review and meta-analysis. J Clin Endocrinol Metab 2007; 92: 2017-29. [DOI:10.1210/jc.2007-0298]
17. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort. Diabetes Care 2006; 29: 2244-6. [DOI:10.2337/dc06-0946]
18. Schwalfenberg G. Vitamin D and diabetes. Can Fam Physician 2008; 54: 864-6.
19. Lee C J, Iyer G, Liu Y, Kalyani RR, Bamba ND, Ligon CB, et al. The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies. J Diabetes Complications 2017; 31: 1115-26. [DOI:10.1016/j.jdiacomp.2017.04.019]
20. Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient–a randomised, placebo-controlled trial. Br J Nutr 2010; 103: 549-55. [DOI:10.1017/S0007114509992017]
21. Iba-ez J, Izquierdo M, Argüelles I, Forga L, Larrión JL, García-Unciti M, et al. Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care 2005; 28: 662-7. [DOI:10.2337/diacare.28.3.662]
22. Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 2004; 53: 294-305. [DOI:10.2337/diabetes.53.2.294]
23. Rice B, Janssen I, Hudson R, Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999; 22: 684-91. [DOI:10.2337/diacare.22.5.684]
24. Shaban N, Gawinski K, Dotzert M, Milne KJ. The effects of high intensity interval training on indices of health in type 2 diabetics. FASEB J 2011; 25: 1057-4.
25. Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen SB, Richelsen B. Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial. Eur J Intern Med 2013; 24: 644-9. [DOI:10.1016/j.ejim.2013.03.005]
26. Maestro B, Molero S, Bajo S, Davila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1, 25‐dihydroxyvitamin D3. Cell Biochem. Funct 2002; 20: 227-32. [DOI:10.1002/cbf.951]
27. Sertznig P, Seifert M, Tilgen W, Reichrath J. Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?. J Steroid Biochem Mol Biol 2010; 121: 383-6. [DOI:10.1016/j.jsbmb.2010.03.003]
28. Byyny RL, Verde ML, Lloyd S, Mitchell W, Draznin B. Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. J Clin Hypertens 1992; 5: 459-64. [DOI:10.1093/ajh/5.7.459]
29. Björklund A, Lansner A, Grill VE. Glucose-induced [Ca2+] i abnormalities in human pancreatic islets: important role of overstimulation. Diabetes 2000; 49: 1840-8. [DOI:10.2337/diabetes.49.11.1840]
30. Chen JJ, Jin H, Ranly DM, Sodek J, Boyan BD. Altered Expression of Bone Sialoproteins in Vitamin D–Deficient rBSP2. 7 Luc Transgenic Mice. J Bone Miner Res 1999; 14: 221-9. [DOI:10.1359/jbmr.1999.14.2.221]
31. Naharci I, Bozoglu E, Kocak N, Doganci S, Doruk H, Serdar M. Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose. Geriatr Gerontol Int 2012; 12: 454-60. [DOI:10.1111/j.1447-0594.2011.00791.x]
32. Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med 2012; 42: 489-509. [DOI:10.2165/11630910-000000000-00000]
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Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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