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:: Volume 17, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2012) ::
SJKU 2012, 17(2): 96-107 Back to browse issues page
Study of the mechanisms and causes related to angiogenesis
Kamran Mansouri 1, Dr Parivash Seifi2, Dr Ali Mostafaie2, Hamid Reza Mohammadi-Motlagh2
1- Kermanshah University of Medical Sciences , kmansouri@kums.ac.ir
2- Kermanshah University of Medical Sciences
Abstract:  
Angiogenesis, the process of new blood vessels formation from existing ones, is important for the normal body growth and development. Angiogenesis is dependent on a delicate equilibrium between endogenous angiogenic and anti-angiogenic factors. If this equilibrium is disturbed, different diseases such as corneal neovascularization, endometriosis, obesity, atherosclerosis, diabetic retinopathy, psoriasis, tumor growth and metastasis may ensue. In general, angiogenesis process is under the influence of several factors and consists of cellular events such as migration, proliferation and differentiation of endothelial cells and finally formation, maturation and remodeling of vessels. Hence, angiogenesis inhibition as a useful measure in conventional therapies such as chemotherapy and radiation has attracted scientists’ attention studying on these issues. In recent years, the angiogenesis control has been considered as a novel idea for control and treatment of angiogenesis-dependent disorders especially tumor growth and metastasis. Because of its importance in causing these disorders, we discuss various aspects of angiogenesis, its mechanisms and causes and also the related studies in this review article.
Keywords: Angiogenesis, Tumor, Anti-angiogenic factors
Full-Text [PDF 699 kb]      
Type of Study: Research | Subject: General
Received: 2012/07/6
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Volume 17, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2012) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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