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:: Volume 12, Number 3 (Scientific Journal of Kurdistan University of Medical Sciences 2007) ::
SJKU 2007, 12(3): 42-49 Back to browse issues page
Comparative study of vitamin B6 versus placebo in premenstrual syndrome
Leili Salehi 1, Farkhondeh salehi
Abstract:  
ABSTRACT Background and Aim: Premenstrual syndrome (PMS) is a psycho-somatic disturbance that occurs during luteal phase. It is estimated that approximately 75% of women experience recurrent physical and psychological symptoms of PMS. The exact cause of this syndrome remains unclear and different methods such as vitamin consumption have been used to cure this syndrome. The aim of this study was to determine the efficacy of vitamin B6 on premenstrual syndrome. Material and Methods: This study was a randomized double blind placebo-controlled study. 92 patients were enrolled into this study and divided into two groups by simple random sampling. Experimental group with 52 subjects receiving 200mg vitB6/daily (five 40mg/day tablets during the whole length of menstrual cycle) and control group with 40 subjects taking 5 starch tablets/day likewise at the same period. Assessment of the symptoms of PMS was performed according to the COPE scale. Data analysis was done by means of X2 and Fisher`s exact statistic tests. Results: The findings of this study showed that vitB6 (200mg/daily) was clinically effective in depression, anxiety, sleepiness (psychological symptoms) and breast tenderness, weight gaining (somatic symptoms) (p<0.05). Placebo also reduced severity of the symptoms but vitamin B6 was superior to the placebo in reducing the symptoms of PMS (p>0.05). The mean age of the subjects in the experimental group was 24.5 and in the control group was 23. The results showed no significant differences between the two groups in relation to mean age, course and field of study. Conclusion: According to the results of this study daily use of vitB6 during menstrual cycle can control PMS symptoms but one must be cautious with high doses of this medicine. Keyword: premenstrual syndrome, vitamin B6 (pyridoxine).
Keywords: premenstrual syndrome, vitamin B6 (pyridoxine).
Full-Text [DOC 170 kb]      
Type of Study: Research | Subject: General
Received: 2009/04/8
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Volume 12, Number 3 (Scientific Journal of Kurdistan University of Medical Sciences 2007) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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