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:: Volume 12, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2007) ::
SJKU 2007, 12(2): 91-96 Back to browse issues page
Two cases of disseminated TB due to BCG vaccination and review of the related articles
dr K Ghadiri , dr M Afsharian, dr S Vaziri, dr F Mansouri, S Namdari
Abstract:  

  ABSTRACT

 Background and Aim: Although BCG vaccination has many benefits, it can cause multiple complications. Disseminated TB is the most severe but rare complication of BCG vaccination. Osteomyelitis is another important complication. Usually these complications are due to a defect in immune system. Rapid diagnosis and treatment can be life saving.

 Results: The first case was a 3 month old boy that was admitted in hospital because of fever, lethargy and fistula in the right axillary area at the site of BCG vaccination. The second one was a 7 month old boy with an ulcer and a fistula at the site of BCG vaccination and chest wall. Diagnosis of disseminated TB was made by biopsy and culture. All immunologic investigations, except interleukin 12-gamma interferon pathway, were normal.

 Conclusion: When a child presents with lymphadenopathy and ulcer near the site of BCG vaccination, the physician must perform a complete physical examination to exclude diagnosis of disseminated TB, especially in the presence of long term low grade fever, organomegally, skin lesions and lack of weight gain.

Keywords: Key words: TB, BCG vaccination, disseminated tuberculosis, osteomyelitis
Full-Text [DOC 393 kb]      
Type of Study: Research | Subject: General
Received: 2009/04/8
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Volume 12, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2007) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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