fa بررسی تغییرات متابولیتهای تالاموس بیماران مبتلا به صرع جنرالیزه ایدیوپاتیک با استفاده از تصویربرداری طیف‌سنجی تشدید مغناطیسی (H1-MRSI) پزشکی- رادیولوژی Medicine - Radiology پژوهشي اصیل Original Research <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">چکیده</span></b><span lang="AR-SA" style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">مقدمه</span></b><span b="" lang="AR-SA" nazanin="" style="font-family:">: صرع جنرالیزه ایدیوپاتیک</span><span dir="LTR" new="" roman="" style="font-family:" times=""> (IGE) </span><span b="" lang="AR-SA" nazanin="" style="font-family:">یک نوع صرع است که مشخصه اصلی آن تشنج‌های جنرالیزه است. <span style="background:yellow">تکنیک تصویربرداری طیف‌سنجی رزونانس مغناطیسی </span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times="">. MRS </span></span><span lang="AR-SA" style="background:yellow"><span b="" nazanin="" style="font-family:">یک روش غیرتهاجمی است که می‌تواند تغییرات متابولیکی مغز را شناسایی کند. مشخصه اختلالات متابولیت در اختلالات تشنجی، کاهش ان استیل اسپارتات </span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times="">&nbsp;&nbsp;(NAA</span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times="">)</span></span><span lang="AR-SA" style="background:yellow"><span b="" nazanin="" style="font-family:">می</span></span> <span lang="AR-SA" style="background:yellow"><span b="" nazanin="" style="font-family:">باشد</span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times="">.</span></span><span lang="AR-SA" style="background:yellow"><span b="" nazanin="" style="font-family:">این مطالعه با هدف بررسی اختلالات تالاموس در بیماران مبتلا به صرع جنرالیزه ایدیوپاتیک </span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times="">IGE</span></span><span style="background:yellow"><span b="" nazanin="" style="font-family:"> با استفاده از </span></span><span lang="FA" style="background:yellow"><span b="" nazanin="" style="font-family:">ا</span></span><span dir="LTR" style="background:yellow"><span new="" roman="" style="font-family:" times=""> MRS</span></span><span lang="AR-SA" style="background:yellow"><span b="" nazanin="" style="font-family:">نجام شد.&nbsp; </span></span><b><span lang="FA" style="font-family:"B Nazanin""></span></b></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">مواد و روش ها</span></b><span b="" lang="AR-SA" nazanin="" style="font-family:">:</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span b="" lang="AR-SA" nazanin="" style="font-family:">این تحقیق بر روی </span><span b="" lang="FA" nazanin="" style="font-family:">۱۰</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> بیمار مبتلا به</span><span dir="LTR" new="" roman="" style="font-family:" times=""> IGE </span><span b="" lang="AR-SA" nazanin="" style="font-family:">و </span><span b="" lang="FA" nazanin="" style="font-family:">۱۰</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> فرد سالم (گروه کنترل) با استفاده از تکنیک</span><span dir="LTR" new="" roman="" style="font-family:" times=""> MRS-CSI </span><span b="" lang="AR-SA" nazanin="" style="font-family:">انجام شد. بیماران و افراد سالم از نظر سن و جنس مشابه بودند.</span> <span b="" lang="AR-SA" nazanin="" style="font-family:">سپس پروتکل </span><span dir="LTR" new="" roman="" style="font-family:" times="">MRS</span><span b="" nazanin="" style="font-family:"> &nbsp;به صورت مولتی وکسل بر روی حجم مورد نظر اعمال شد. تجزیه و تحلیل داده‌ها با استفاده از آزمون آماری</span><span dir="LTR" new="" roman="" style="font-family:" times=""> t-test </span><span b="" lang="AR-SA" nazanin="" style="font-family:">صورت گرفت</span><span dir="LTR" new="" roman="" style="font-family:" times="">.</span><span lang="AR-SA" style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">نتایج</span></b><span b="" lang="AR-SA" nazanin="" style="font-family:">: نتایج نشان داد که غلظت </span><span dir="LTR" new="" roman="" style="font-family:" times="">&nbsp;NAA/Cr</span><span b="" lang="AR-SA" nazanin="" style="font-family:">در تالاموس بیماران مبتلا به </span><span dir="LTR" new="" roman="" style="font-family:" times="">IGE</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> در مقایسه با افراد سالم به طور غیر طبیعی پایین&shy;تر است. اما تفاوتی در غلظت </span><span dir="LTR" new="" roman="" style="font-family:" times="">NAA/Cr</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> در قشر اینسولا، و جسم پینه&shy;ای دیده نشد. همچنین <span style="background:yellow">در آزمون</span> </span><span dir="LTR" new="" roman="" style="font-family:" times="">T-test</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> اختلاف معناداری در مقادیر نسبت </span><span dir="LTR" new="" roman="" style="font-family:" times="">NAA/Cho</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> در بین گروه بیمار و گروه کنترل یافت نشد. &nbsp;&nbsp;</span><span dir="LTR" style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">نتیجه‌گیری</span></b><span b="" lang="AR-SA" nazanin="" style="font-family:">: مطالعه حاضر نشان می‌دهد <span style="background:yellow">که</span></span> <span lang="FA" style="background:yellow"><span b="" nazanin="" style="font-family:">احتمالا</span></span><span b="" lang="AR-SA" nazanin="" style="font-family:"> تالاموس در پاتوفیزیولوژی صرع ایدیوپاتیک نقش دارد و کاهش نسبت</span><span dir="LTR" new="" roman="" style="font-family:" times=""> NAA/Cr </span><span b="" lang="AR-SA" nazanin="" style="font-family:">می‌تواند به‌عنوان یک شاخص متابولیکی برای شناسایی اختلالات نورونی در این بیماری مورد استفاده قرار گیرد. این یافته‌ها ارزش استفاده از</span><span dir="LTR" new="" roman="" style="font-family:" times=""> MRS </span><span b="" lang="AR-SA" nazanin="" style="font-family:">در مطالعات بالینی صرع را تایید می‌کنند</span><span dir="LTR" new="" roman="" style="font-family:" times="">.</span><span lang="AR-SA" style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="AR-SA" nazanin="" style="font-family:">کلمات</span></b><b> </b><b><span b="" lang="AR-SA" nazanin="" style="font-family:">کلیدی</span></b><span b="" lang="AR-SA" nazanin="" style="font-family:">: صرع ایدیوپاتیک، تالاموس، تصویربرداری تشدید مغناطیسی، طیف سنجی تشدید</span> <span b="" lang="AR-SA" nazanin="" style="font-family:">مغناطیسی.</span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Abstract</span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></b> <span style="background:yellow"><span new="" roman="" style="font-family:" times="">Idiopathic Generalized Epilepsy (IGE) is a type of epilepsy characterized primarily by generalized seizures. Magnetic Resonance Spectroscopy (MRS) is a non-invasive imaging technique capable of detecting metabolic alterations in the brain. A hallmark of metabolic abnormalities in seizure disorders is a reduction in N-acetylaspartate (NAA). This study was conducted to investigate thalamic abnormalities in patients with Idiopathic Generalized Epilepsy using Magnetic Resonance Spectroscopy (MRS).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b> <span style="background:yellow"><span new="" roman="" style="font-family:" times="">This study was performed on 10 patients diagnosed with IGE and 10 healthy subjects serving as the control group, using the MRS Chemical Shift Imaging (MRS-CSI) technique. Patients and controls were matched for age and sex. A multivoxel MRS protocol was applied to the region of interest. Data analysis was carried out using the independent samples t-test.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="background:yellow"><span new="" roman="" style="font-family:" times="">The findings demonstrated that the NAA/Cr ratio in the thalamus of patients with IGE was abnormally lower than that of healthy controls. However, no significant differences were observed in the NAA/Cr ratio within the insular cortex or the corpus callosum. Furthermore, the t-test analysis revealed no statistically significant difference in the NAA/Cho ratio between the patient and control groups.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b> <span style="background:yellow"><span new="" roman="" style="font-family:" times="">The present study suggests that the thalamus may play a role in the pathophysiology of Idiopathic Generalized Epilepsy. The observed reduction in the NAA/Cr ratio may serve as a metabolic marker for identifying neuronal abnormalities associated with this disorder. These findings support the value of MRS as a useful tool in the clinical investigation of epilepsy.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="background:yellow"><span new="" roman="" style="font-family:" times="">Keywords:</span></span></b> <span style="background:yellow"><span new="" roman="" style="font-family:" times="">Idiopathic Epilepsy; Thalamus; Magnetic Resonance Imaging (MRI); Magnetic Resonance Spectroscopy (MRS).</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> کلمات کلیدی: صرع ایدیوپاتیک، تالاموس، تصویربرداری تشدید مغناطیسی، طیف سنجی تشدید مغناطیسی idiopathic generalized epilepsy, thalamus, proton magnetic resonance spectroscopic imaging, MRI. 0 0 http://sjku.muk.ac.ir/browse.php?a_code=A-10-5010-3&slc_lang=fa&sid=1 meysam mirzaie peyhani میثم میرزائی پیهانی meysam.mirzaie@yahoo.com 3934442633 5400319475328460073008 No fariborz faeghi فریبرز فائقی f_faeghi@sbmu.ac.ir 5400319475328460073009 5400319475328460073009 Yes farid zayeri فرید زایری fzayeri@yahoo.com 5400319475328460073010 5400319475328460073010 No